| Titre : | Bioinformatics Characterization Porphyrin Protein Research on based Prophyrin Proteins Binding of Structural Motifs Binding Structural Motifs and Construction of a relevant Database: URL : https://bioinformatics.univ-saida.dz/prjs/ppbsmtfs/ Unravelling some Essentials of Protein Structure-Function Relationships |
| Auteurs : | Abdelkrim Rachedi, Directeur de thèse ; Megherbi Mohamed El Mehdi, Auteur |
| Type de document : | texte imprimé |
| Mention d'édition : | ط 1 |
| Année de publication : | 2023 |
| Format : | 70ص / 24 سم |
| Langues: | Arabe |
| Mots-clés: | Porphyrin proteins, Porphyrin ligands, Heme, Chlorophyll, B12, Structural Bioinformatics Structural & Functional Motifs, Ligand Binding Environment, Amino Acids, Residues, Databases |
| Résumé : |
This project seeks to explore more the basis behind Structure-Function relationship in
biological context of macromolecules; the proteins in the case of this study. Furthermore, the study draws attention to results that would touch upon distant evolutionary relations across species. The understanding of the structure-function relationship in important for deeper studies of the subject of biological function of proteins, and macromolecules in general, in both health and disease situations. One way to undertake the kind of study is to analyse the proteins structures involved in selected biological functions and examine their ligand binding environments. In this project, a set of 3D-structures of porphyrin proteins representing 51 full chains from 21 Protein Databank (PDB) entries from different source organism or species have been studied in terms of their binding sites environment around and number porphyrin groups. Thus study implemented structural bioinformatics tools developed at the Department of Biology, Then University of Saida, The study resulted in the identified and construction a set of 43 unique Structural and Functional Binding Motifs what have been characterised and analysed their binding site residues content and properties. These motifs are associated with a number of vital biological functions including oxygen transport, storage, light harvesting and energy production and more. The data and analysis pertaining to this project have been stored in a Flat-File database type named as Porphyrin Proteins Binding Structural Motifs – PPBSMs . The database PPBSMs has been made available online for the world wide community of scientist and researchers though the Web-server of University of Saida via the following web- address: https://bioinformatics.univ-saida.dz/prjs/ppbsms/ |
Exemplaires (1)
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| snvtm000964 | BIOTM00964 | Périodique | Salle des Thèses | biologie | Consultation sur place Exclu du prêt |
Documents numériques (1)
Bioinformatics Characterization Porphyrin Protein Research on based Prophyrin Proteins Binding of Structural Motifs Binding Structural Motifs and Construction of a relevant Database: URL : https://bioinformatics.univ-saida.dz/prjs/ppbsmtfs/ Unravelling so Adobe Acrobat PDF |
